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ONTOLOGY REPORT - ANNOTATIONS

Term:de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
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Accession:GO:0098535 term browser browse the term
Definition:Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation.
Comment:In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.
Synonyms:exact_synonym: de novo centriole assembly via deuterosome
 broad_synonym: de novo centriole assembly
 related_synonym: centriole amplification;   deuterosomal basal body biogenesis;   deuterosome pathway;   deuterosome-mediated centriole biogenesis;   multiciliation;   multiciliogenesis

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de novo centriole assembly involved in multi-ciliated epithelial cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCDC78 coiled-coil domain containing 78 involved_in ISO (PMID:24075808) UniProt PMID:24075808 NCBI chr 5:642,500...646,337 JBrowse link
G CEP152 centrosomal protein 152 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:34,473,648...34,608,650
Ensembl chr26:34,473,757...34,546,842 		JBrowse link
G CEP63 centrosomal protein 63 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr15:55,821,117...55,892,951
Ensembl chr15:55,821,487...55,892,398 		JBrowse link
G DEUP1 deuterosome assembly protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:84,579,296...84,678,064
Ensembl chr 1:84,580,213...84,678,661 		JBrowse link
G PLK4 polo like kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:75,005,468...75,023,768
Ensembl chr 7:75,006,431...75,023,730 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16925
    cellular process 15887
      cellular developmental process 4455
        cell differentiation 4454
          epithelial cell differentiation 802
            multi-ciliated epithelial cell differentiation 7
              de novo centriole assembly involved in multi-ciliated epithelial cell differentiation 5
Path 2
Term Annotations click to browse term
  biological_process 16925
    cellular process 15887
      cellular component organization or biogenesis 6765
        cellular component organization 6524
          organelle organization 3662
            cytoskeleton organization 1524
              microtubule cytoskeleton organization 684
                microtubule organizing center organization 152
                  centriole assembly 44
                    de novo centriole assembly 6
                      de novo centriole assembly involved in multi-ciliated epithelial cell differentiation 5
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